The single-cell transcriptomic atlas iPain identifies senescence of nociceptors as a therapeutical target for chronic pain treatment

Abstract Chronic pain remains a significant medical challenge with complex underlying mechanisms, and an urgent need for new treatments.Our research built and utilized the iPain single-cell atlas to Hookah study chronic pain progression in dorsal root and trigeminal ganglia.We discovered that senescence of a small subset of pain-sensing neurons may

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Comparative evaluation of gingival response following the placement of light-cured dressing and noneugenol dressing after periodontal flap surgery: A clinical study

Aim: The aim of the study was to compare light-cured dressing with most widely used noneugenol pack in the perspective of esthetics, acceptance, and healing following periodontal flap surgery.Materials and Methods: Fifty-eight patients suffering from generalized chronic periodontitis, requiring periodontal flap surgery on contralateral sides of the

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Photoevaporation and Close Encounters: How the Environment around Cygnus OB2 Affects the Evolution of Protoplanetary Disks

In our Galaxy, star formation occurs in a variety of environments, with a large fraction of stars formed in clusters hosting massive stars.OB stars have an important feedback on the evolution of protoplanetary disks orbiting around nearby young stars and likely on the process of Cat Food-Raw planet formation occurring in them.The nearby massive ass

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Shifting cancer care towards Multidisciplinarity: the cancer center certification program of the German cancer society

Abstract Background Over the last decades numerous initiatives have been set up that aim at translating the best available medical knowledge and treatment into clinical practice.The inherent complexity of the programs and discrepancies in the terminology used make it difficult to appreciate each of them distinctly and compare their specific strengt

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